Medically reviewed by Drugs. Last updated on Jan 1, Doxycycline is a broad-spectrum antibacterial synthetically derived from oxytetracycline. Doxycycline capsules USP, 75 mg, and mg contain Doxycycline monohydrate equivalent to 75 mg, and mg of Doxycycline for oral administration. Doxycycline has a high degree of lipid solubility and a low affinity for calcium binding. It is highly stable in normal human serum.
Doxycycline will not degrade into an epianhydro form. The capsules are printed with edible ink containing shellac, titanium dioxide, black iron oxide, brown iron oxide and potassium hydroxide for 75 mg and mg strengths. Tetracyclines are readily absorbed and are bound to plasma proteins in varying degrees. They are concentrated by the liver in the bile and excreted in the urine and feces at high concentrations in a biologically active form.
Doxycycline is virtually completely absorbed after oral administration. Following a mg dose of Doxycycline monohydrate, 24 normal adult volunteers averaged the following serum concentration values:. Studies have shown no significant difference in serum half-life of Doxycycline range 18 to 22 hours in individuals with normal and severely impaired renal function.
Doxycycline inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. Doxycycline has bacteriostatic activity against a broad range of Gram-positive and Gram-negative bacteria. Anaerobic Bacteria Clostridium species Fusobacterium fusiforme Propionibacterium acnes. Other Bacteria Nocardiae and other Actinomyces species Borrelia recurrentis Chlamydophila psittaci Chlamydia trachomatis Mycoplasma pneumoniae Rickettsiae Treponema pallidum Treponema pallidum subspecies pertenue Ureaplasma urealyticum.
Parasites Balantidium coli Entamoeba species. These reports should aid the physician in selecting the most effective antimicrobial. Quantitative methods are used to determine antimicrobial minimum inhibitory concentrations MICs. These MICs provide estimates of the susceptibility of bacteria to antimicrobial compounds.
Quantitative methods that require measurement of zone diameters can also provide reproducible estimates of the susceptibility of bacteria to antimicrobial compounds. The zone size should be determined using a standardized test method. The disk diffusion interpretive criteria are provided in Table 1.
For anaerobic bacteria, the susceptibility to Doxycycline can be determined by a standardized test method. A report of Susceptible S indicates that the antimicrobial is likely to inhibit growth of the microorganism if the antimicrobial drug reaches the webseries softhub usually achievable at the site of infection.
A report of Intermediate I indicates that the result should be considered equivocal, and, if the microorganism is not fully susceptible to alternative, clinically feasible drugs, the test should be repeated. This category implies possible clinical applicability in body sites where the drug product is physiologically concentrated or in situations where high dosage rossi m92 ranch hand drug can be used.
This category also provides a buffer zone that prevents small uncontrolled technical factors from causing major discrepancies in interpretation. A report of Resistant R indicates that the antimicrobial drug is not likely to inhibit growth of the microorganism if the antimicrobial drug reaches the concentrations usually achievable at the infection site; other therapy should be selected.
Standardized susceptibility test procedures require the use of laboratory controls to monitor and ensure the accuracy and precision of the supplies and reagents used in the assay, and the techniques of the individuals performing the test.
For the diffusion technique using the 30 mcg Doxycycline disk or 30 mcg tetracycline disk, the criteria noted in Table stm32 spi flash memory should be achieved.
To reduce the development of drug-resistant bacteria and maintain effectiveness of Doxycycline capsules, USP and other antibacterial drugs, Doxycycline capsules, USP should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy.If these effects are mild, they may go away within a few days or a couple of weeks.
Call your doctor right away if you have serious side effects. Serious side effects and their symptoms can include the following:. Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects.
This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history. Generic drugs usually cost less. In some cases, they may not be available in every strength or form as the brand-name version. Doxycycline tablets come in immediate-release and delayed-release forms. Doxycycline also comes in two other oral forms: capsule and solution. In addition, doxycycline comes in a solution for injection, which is only given by a healthcare provider.
Doxycycline is used to treat bacterial infections. These can include some sexually transmitted diseases, skin infections, eye infections, respiratory infections, and more. It is also used as an add-on treatment for severe acne and to prevent malaria in people who plan to travel to areas with certain strains of malaria.
This drug may be used as part of a combination therapy. This means you may need to take it with other medications. Doxycycline belongs to a class of drugs called tetracyclines. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions. This drug works by blocking a bacterial protein from being made. It does this by binding to certain units of the protein.
This stops the protein from growing and treats your infection. Doxycycline oral tablet can interact with other medications, vitamins, or herbs you may be taking.
An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well. To help avoid interactions, your doctor should manage all of your medications carefully. Do not use these drugs with doxycycline.
Doing so can cause dangerous effects in your body. Examples of these drugs include:. When you take doxycycline with certain drugs, doxycycline may not work as well to treat your condition.
This is because the amount of doxycycline in your body may be decreased. Examples of drugs that can cause this type of interaction include:.Back to Medicines A to Z. It's used to treat infections such as chest infectionsskin infections, rosaceadental infections and sexually transmitted infections STIsas well as a lot of other rare infections. It can also be used to prevent malaria if you're travelling abroad. Doxycycline can be taken by adults and children over 12 years old.
Doxycycline is not usually recommended in pregnancy or when breastfeeding. It isn't suitable for some people. To make sure this medicine is safe for you, tell your doctor if you have :. The usual dose is mg to mg once or twice a day. If you're taking doxycycline more than once a day, try to space your doses evenly throughout the day.
If you take it twice a day, this could be first thing in the morning, and in the evening.
Tick Bite Prophylaxis
For preventing malaria, you'll take mg once a day, usually in the morning. You should start taking doxycycline 1 or 2 days before going to an area where there is malaria. Carry on for 4 weeks after leaving the area. Check with your doctor or pharmacist that doxycycline is the best medicine to prevent malaria in the country you are travelling to.
Carry on taking doxycycline until you've completed the course, even if you feel better. If you stop your treatment early, the infection could come back - or you may no longer be protected against malaria. Always swallow your doxycycline capsule whole and have it with a full glass of water a medium sized glass - ml. You can take this medicine with or without food.
However you're less likely to feel sick if you have it with food. It's important to take doxycycline while you're in an upright position. You can be sitting, standing or walking. This will stop the medicine irritating your food pipe or stomach. If you forget to take a dose, take it as soon as you remember, unless it's nearly time for your next dose.
In this case, just leave out the missed dose and take your next dose as normal. If you often forget doses, it may help to set an alarm to remind you. You could also ask your pharmacist for advice on other ways to remember your medicines. These common side effects happen in around 1 in 10 people. Keep taking the medicine, but talk to your doctor or pharmacist if these side effects bother you or don't go away:. In rare cases, doxycycline can cause a serious allergic reaction anaphylaxis.
These are not all the side effects of doxycycline. For a full list see the leaflet inside your medicines packet. You can report any suspected side effect to the UK safety scheme. Tell your doctor if you're taking these medicines before you start taking doxycycline :. Typhoid vaccine given by mouth may not work properly if you're taking doxycycline. If you need a typhoid vaccine while taking doxycycline, your doctor or nurse will give it by injection.
For safety, tell your doctor or pharmacist if you're taking any other medicines, including herbal remedies, vitamins or supplements.Doxycycline is in a class of medications called tetracyclines, and it's a broad-spectrum antibiotic, which means it works against a wide range of bacteria.
Doctors prescribe doxycycline to prevent malaria and treat a wide range of infections, including:. Like all antibioticsdoxycycline will not treat colds, the fluor other infections caused by viruses or fungi. A study found that a low dose of 40 milligrams mg of slow-release doxycycline daily could be an effective and safe therapy for ocular rosacea, or rosacea that affects the eyes.
The drug company Pfizer developed doxycycline in the early s, and the Food and Drug Administration FDA approved the drug in under the brand name Vibramycin.
It's sometimes used as an alternative to another acne drug with more side effects, minocycline. However, a study published in found that people with acne who used an antibiotic-free facial gel had greatly improved acne, according to MedPage Today. You should take this medication only to treat bacterial infections, and it's important to take it exactly as your doctor prescribes. Using doxycycline or other antibiotics incorrectly or using them to treat infections caused by other types of germs, such as viruses, contributes to the development of drug-resistant bacteria.
Every time you take an antibiotic, it kills the sensitive bacteria. Resistant germs, however, can grow and multiply, and then surviving bacteria can become resistant. It's also important to understand that taking antibiotics, including doxycycline, alters the normal balance of bacteria in your body.
In addition to killing harmful bacteria, the medication can also reduce the amount of good bacteria that help keep other germs in check.
As a result, some people taking doxycycline develop yeast infections and antibiotic-related diarrhea. Taking doxycycline could make oral birth control pills less effective. If you are on oral contraceptives, you should use other forms of birth control while you take this antibiotic. Before taking doxycycline, let your doctor know if you're going to have any kind of surgery, including dental surgery. Also tell your doctor if you have diabetes.
Taking doxycycline can interfere with tests for sugar in the urine. Tetracyclines, including doxycycline, also pass into breast milk, so women who are breastfeeding should not take this drug.Doxycycline is an antibiotic that can be used to treat bacterial infections in dogs.
It is a broad-spectrum antibiotic, which means it can fight multiple types of bacteria. The drug is often prescribed for dogs to treat tick borne diseases like Lyme disease, Rocky Mountain spotted fever, and ehrlichiosis. If your veterinarian has prescribed doxycycline for your dog, then it is important that you follow their guidelines carefully and give your dog the medication for the full regimen that your vet advises.
If you notice side effects, inform your veterinarian so they can create a treatment plan and make your dog more comfortable. As a broad-spectrum antibiotic, doxycycline can treat infections from many different kinds of bacteria in dogsthough it is not effective for treating viral or fungal infections.
Vets may prescribe it as a preventative measure while treating one infection to prevent a secondary bacterial infection from occurring. Your veterinarian may also prescribe doxycycline to treat one of the following conditions in your dog:.
The common dosage of doxycycline for dogs is 2 mg to 5 mg per pound of body weight given every 12 to 24 hours. Your dog should have plenty of fresh water available at all times for the duration of the medication regimen. Side effects of doxycycline in dogs are fairly rare. Most adult dogs tolerate the drug well. The most common side effects in dogs include nausea, vomiting, or difficulty swallowing or breathing.
Swallowing or breathing problems can be reduced by following the tablet up with a small amount of water. If gastrointestinal problems become severe, then you should contact your veterinarian, as this can be a sign of doxycycline overdose. Doxycycline can cause limb deformities in puppies still in the womb, which is also risky for pregnant mother dogs. Sometimes a veterinarian will decide that the benefits outweigh the risks of the antibiotic. Doxycycline can also interact poorly with other drugs, so make sure your vet is aware of any other medications your pet is taking.
As with almost all medications, there is a risk of allergic reaction that can lead to anaphylaxis. If you see signs of an allergic reaction, then you should contact your veterinarian immediately. Picture Credit: Getty Images.Doxycycline is a tetracycline antibiotic which inhibits protein synthesis and alters the permeability of cytoplasmic membranes in bacterial cells.
It is a common choice of antibiotic for use in dogs with azotemia as it can safely be given to those with impaired kidney function.Acne UPDATE! Side Affects Of Doxycycline & Finally Clearer Skin!
A typical dosage of doxycycline for dogs is 1. Drew recommends a higher dosage of 2. Always follow the recommendation of your vet. The following chart shows a dosage of 2. All injections should be given intravenously into the bloodstream. Avoid intramuscular or subcutaneous injection. For detailed instructions regarding the use of the gel and the amount to use please visit Zoetis. Care must be taken to avoid superinfections of bacteria and fungi which are not susceptible to the drug.
Rapid IV injection of the drug in overdose amounts could potentially lead to irregular heartbeat and more serious cardiac effects based on the reactions of other species.
If use on a pregnant dog is unavoidable, use of the medicine during the last half of pregnancy is possible. We recommend the following guidelines when using this medicine to treat your dog:.
Do not administer this medicine orally alongside antacids. Doing so could inhibit the absorption of the medicine.
Do not give to dogs who have shown hypersensitivity to this drug or any other tetracycline antibiotics in the past. Doxycycline is an antibiotic, it can treat many different bacterial infections and is usually the drug of choice for treating Rocky Mountain Spotted Fever as well as several other tick-borne diseases.
Side effects are usually limited to gastric upset. Incidence of vomiting and nausea can be reduced significantly by administering the drug alongside food. In larger amounts weight loss has been noted. In rare cases superinfections may develop following the use of this medicine due to the growth of bacteria and fungi which are resistant to the drug. Sources Dr. Drew Dr. Hartmann Dr. Toggle navigation. Home Dog Medicine. Example: Your vet could choose to treat a 40 lb dog with mg per dose, which is equal to one mg tablet per dose.People treated with appropriate antibiotics in the early stages of Lyme disease usually recover rapidly and completely.
Antibiotics commonly used for oral treatment include doxycycline, amoxicillin, or cefuroxime axetil. People with certain neurological or cardiac forms of illness may require intravenous treatment with antibiotics such as ceftriaxone or penicillin.
Doxycycline For Dogs
Treatment regimens listed in the following table are for localized early Lyme disease. See references below Hu ; Sanchez for treatment of patients with disseminated late Lyme disease. NOTE: For people intolerant of amoxicillin, doxycycline, and cefuroxime axetil, the macrolides azithromycin, clarithromycin, or erythromycin may be used, although they have a lower efficacy. People treated with macrolides should be closely monitored to ensure that symptoms resolve.
The National Institutes of Health NIH has funded several studies on the treatment of Lyme disease that show most people recover when treated within a few weeks of antibiotics taken by mouth. In a small percentage of cases, symptoms such as fatigue being tired and muscle aches can last for more than 6 months. Skip directly to site content Skip directly to page options Skip directly to A-Z link.
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